Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses

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• 作者：Miguel A. Martí ; n-Acebes ; ^{martin.mangel@inia.es} ; Á ; ngela Vá ; zquez-Calvo ; Juan-Carlos Saiz
• 关键词：ACC ; Acetyl-CoA carboxylase ; BMP ; bis(monoacylglycero)phosphate ; BVDV ; bovine viral diarrhea virus ; CERS ; ceramide synthase ; CoA ; Coenzyme A ; COX-2 ; cyclooxygenase-2 ; DENV ; dengue virus ; DHCR7 ; 7-dehydrocholesterol reductase ; dsRNA ; double-stranded RNA ; ER ; endoplasmic reticulum ; FASN ; fatty acid synthase ; Gas6/ProS ; Growth-arrest-specific 6 and protein S ; GGTase1 ; geranylgeranyl transferase type 1 ; HCV ; hepatitis C virus ; HMG-CoA reductase ; hydroxyl methyl glutaryl-CoA reductase ; JEV ; Japanese
• 刊名：Progress in Lipid Research
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：64
• 期：Complete
• 页码：123-137
• 全文大小：2187 K
• 卷排序：64

文摘

Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur Forest disease, tick-borne encephalitis, or Zika disease. This viral genus groups > 50 viral species of small enveloped plus strand RNA virus that are phylogenetically closely related to hepatitis C virus. Importantly, the flavivirus life cycle is intimately associated to host cell lipids. Along this line, flaviviruses rearrange intracellular membranes from the endoplasmic-reticulum of the infected cells to develop adequate platforms for viral replication and particle biogenesis. Moreover, flaviviruses dramatically orchestrate a profound reorganization of the host cell lipid metabolism to create a favorable environment for viral multiplication. Consistently, recent work has shown the importance of specific lipid classes in flavivirus infections. For instances, fatty acid synthesis is linked to viral replication, phosphatidylserine and phosphatidylethanolamine are involved on the entry of flaviviruses, sphingolipids (ceramide and sphingomyelin) play a key role on virus assembly and pathogenesis, and cholesterol is essential for innate immunity evasion in flavivirus-infected cells. Here, we revise the current knowledge on the interactions of the flaviviruses with the cellular lipid metabolism to identify potential targets for future antiviral development aimed to combat these relevant health-threatening pathogens.