Differences among HIV-1 subtypes in drug resistance against integrase inhibitors

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• 作者：Ying-Shan Han^a ; Thibault Mesplè ; de^a ; Mark A. Wainberg^a ; ^b ; ^c ; ^{mark.wainberg@mcgill.ca}
• 关键词：Drug resistance ; HIV subtypes ; Integrase inhibitors
• 刊名：Infection, Genetics and Evolution
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：Complete
• 页码：286-291
• 全文大小：276 K
• 卷排序：46

文摘

Use of integrase inhibitors is less prone to development of drug resistance. Integrase inhibitors should be available for first-line therapy worldwide. Use of integrase inhibitors will diminish rates of transmitted drug resistance. The use of dolutegravir may forestall the development of resistance. Subtype differences can be important in drug resistance.