A Novel Technique for Amniotic Membrane Transplantation in Patients with Acute Stevens-Johnson Syndrome

详细信息    查看全文

• 作者：Kelly N. Ma ; MD ; MPH¹ ; ^&lowast ; ; Aristomenis Thanos ; MD² ; ^&lowast ; ; James Chodosh ; MD ; MPH² ; Ankoor S. Shah ; MD ; PhD² ; ³ ; Iason S. Mantagos ; MD² ; ³ ; ^{jason.mantagos@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：amniotic membrane ; cryopreserved amniotic membrane ; ocular surface ; Stevens-Johnson syndrome ; transplantation
• 刊名：The Ocular Surface
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：14
• 期：1
• 页码：31-36
• 全文大小：733 K

文摘

Cryopreserved amniotic membrane (AM) transplantation is an emerging technique that is becoming the gold standard for the management of acute Stevens-Johnson syndrome (SJS) and its more severe variant, toxic epidermal necrolysis (TEN). We describe a novel surgical technique utilizing a single, large sheet of AM (5 x 10 cm) and a custom-made forniceal ring, which facilitates AM placement. Our technique is easy to use and minimizes suturing and manipulation of ocular tissues, resulting in decreased operative time. This technique may be applied in the management of multiple ocular surface disease processes, including chemical or thermal burns, severe ocular graft versus host disease (GVHD), and other autoimmune diseases.