Meroterpenoid enantiomers from Ganoderma sinensis

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• 作者：Wen-Wen Cao^a ; ^b ; Qi Luo^b ; ^c ; Yong-Xian Cheng^b ; ^{yxcheng@mail.kib.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Shu-Mei Wang^a ; ^{shmwang@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fornicin A (PubChem CID ; 16086601)
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：110
• 期：Complete
• 页码：110-115
• 全文大小：402 K

文摘

Zizhines A–F (1–6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods. All the compounds apart from 7 were evaluated for their inhibition on extracellular matrix component (fibronectin) generation by using TGF-β1-induced rat kidney tubular epithelial cells. Although none of them was found to be active in these cells, the present findings add new facets for the chemistry of Ganoderma.