White matter abnormalities in the fornix are linked to cognitive performance in SZ but not in BD disorder: An exploratory analysis with DTI deterministic tractography
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- 作者：Christian Knö ; chela ; Christian.Knoechel@kgu.de" class="auth_mail" title="E-mail the corresponding author ; Claudia Schmieda ; David E.J. Lindenc ; Michael Stä ; bleina ; David Prvulovica ; Luiza de A. de Carvalhod ; Octavia Harrisona ; b ; Paulo O. Barros Juniord ; André ; F. Carvalhod ; Andreas Reifa ; Gilberto S. Alvesd ; 1 ; Viola Oertel-Knö ; chela ; 1
- 关键词：BD ; bipolar disorder ; DTI ; diffusion tensor imaging ; FA ; fractional anisotropy ; Vol ; tract volume ; Le ; tract length ; NofT ; number of tracts ; VBM ; voxel based morphometry ; WM ; white matter ; MD ; mean diffusivity ; CC ; corpus callosum ; SCID ; Structured Clinical Interview for the DSM IV ; BDI II ; Beck Depression Inventory ; BRMAS ; Bech Rafaelsen Mania Scale ; MWT-B ; Mehrfachwahl-Wortschatz-Test ; TMT ; Trail Making Test ; EPI ; echo planar imaging ; ATR ; anterior thalamic radiation ; F ; Fornix ; C ; Cingulum
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：201
- 期：Complete
- 页码：64-78
- 全文大小：1624 K
文摘
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We employed deterministic tractography to detect altered crossing fibers in the fornix, the cingulum, the anterior thalamic radiation and the corpus callosum BD and SZ patients.
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We showed lower FA and Le in the left and right fornices in patients with BD and SZ.
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Widespread fiber tracking scores differences in SZ compared with controls.
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Associations between cognitive and sociodemographic variables and microstructural integrity in the fornix.
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Findings support current pathophysiological models, indicating abnormal fronto-limbic connections.