The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells
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- 作者：C.T.D. Kwoka ; M.H. Leunga ; J. Qina ; d ; Y. Qina ; J. Wangc ; Y.L. Leeb ; cherielee@hku.hk" class="auth_mail" title="E-mail the corresponding author ; K.-M. Yaoa ; kmyao@hku.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：hESCs ; human embryonic stem cells ; ES cells ; embryonic stem cells ; CDK ; cyclin-dependent kinases ; EC cells ; embryonal carcinoma cells ; EB ; embryoid bodies ; PI ; propidium iodide ; ROS ; reactive oxygen species ; GO ; gene ontology ; RPE ; retinal pigment epithelium ; RA ; retinoic acid ; bFGF ; basic fibroblast growth factor 2 ; CM ; conditioned medium ; DE ; definitive endoderm ; AVBF medium ; medium based on Stemline II Hematopoietic Stem Cell expansion medium supplemented with BMP4 ; hFF ; human foreskin fibrob
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：16
- 期：3
- 页码：651-661
- 全文大小：1513 K
文摘
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FOXM1 is expressed in undifferentiated hESCs with peak levels at G2/M phase.
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FOXM1 depletion causes mitotic defect and delays G2/M progression in hESCs.
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FOXM1 downregulation does not induce rapid exit of undifferentiated state in hESCs.
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FOXM1 depletion sensitizes hESCs to oxidative stress.
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Genomic binding profile of FOXM1 in hESCs differs substantially from cancer cells.