FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance
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- 作者：Gabriela Nestal de Moraesa ; b ; Deborah Delbuea ; Karina L. Silvac ; Marcela Cristina Robainaa ; Pasarat Khongkowb ; Ana R. Gomesb ; Stefania Zonab ; Susanne Crocamod ; André ; Luiz Mencalhae ; Lí ; dia M. Magalhã ; esf ; Eric W.-F. Lamb ; Raquel C. Maiaa ; rcmaia@inca.gov.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：ChIP ; chromatin immunoprecipitation ; FHRE ; forkhead responsive elements ; FISH ; fluorescence in situ hybridization ; FOX ; forkhead box ; HR ; hormone receptor ; IAP ; inhibitor of apoptosis protein ; IHC ; immunohistochemistry ; MTT ; 3-(4 ; 5-dimethylthiazlol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; PBS ; phosphate saline buffer ; siRNA ; small interfering RNA ; TMA ; tissue microarray
- 刊名：Cellular Signalling
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：27
- 期：12
- 页码：2496-2505
- 全文大小：1546 K
文摘
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In drug resistant cells, XIAP and Survivin expression is upregulated by FOXM1.
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XIAP and Survivin levels are inhibited in FOXM1-depleted breast cancer cells.
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FOXM1 knockdown results in decreased binding to XIAP and Survivin gene promoters.
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In breast cancer patients, FOXM1 is associated with XIAP and Survivin expression.
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Co-expression of FOXM1, Survivin, and nuclear XIAP impacts breast cancer survival.