刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:8 January 2017
年:2017
卷:482
期:2
页码:329-334
全文大小:943 K
卷排序:482
文摘
Ifrd1 expression is upregulated by BMP-2 in osteoblasts at the transcriptional level. Smad4/Smad1 stimulates Ifrd1 promoter activity in osteoblasts. BMP-2 accelerates recruitment of Smad1 to the Ifrd1 promoter in osteoblasts. Ifrd1 knockdown enhances BMP-2-dependent osteoblastogenesis.