Nox-2 up-regulation and platelet activation: Novel insights
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- 作者：Daniele Pastoria ; 1 ; Pasquale Pignatellia ; 1 ; Roberto Carnevalea ; b ; Francesco Violia ; francesco.violi@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Platelets ; Oxidative stress ; Nox ; Reactive oxygen species ; Isoprostanes
- 刊名：Prostaglandins and Other Lipid Mediators
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：120
- 期：Complete
- 页码：50-55
- 全文大小：952 K
文摘
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Platelet Nox-related O2− formation enhances platelet activation and aggregation.
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Nox2 activation has a major role in the formation of platelet 8-iso-PGF2伪.
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Nox2 is up-regulated in patients with atherosclerotic diseases.
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Atorvastatin reduces Nox2 activation and 8-iso-PGF2伪 formation.
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Extra virgin olive oil blunts post-prandial Nox2-related oxidative stress.