Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.
Diterpenes and rosmarinic acid were tested against cholinesterase enzymes. QSAR and molecular docking studies have been also performed on the active compounds. All of the compounds showed higher or closer inhibition against BChE. In silico data well-matched with the in vitro outcomes of the present study. 15,16-Dihydrotanshinone is promising due to its dual inhibition toward both enzymes.