Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats
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- 作者：Saad H. Mullaha ; ; Biswajit K. Sahaa ; Rania Abutarbousha ; Peter B. Walkera ; Ashraful Haquea ; Francoise G. Arnauda ; b ; Brittany Hazzarda ; Charles R. Aukera ; b ; Richard M. McCarrona ; b ; Anke H. Scultetusa ; b ; Paula Moon-Massata
- 关键词：DDFP ; Dodecafluoropentane ; PbtO2 ; Brain tissue oxygen tension ; PFC ; Perfluorocarbons ; PQM ; Phosphorescence Quenching Method
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：1634
- 期：Complete
- 页码：132-139
- 全文大小：545 K
文摘
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Baseline cerebral cortical PbtO2 was 28±3 mm Hg.
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CCI-TBI resulted in a 46±6% reduction in PbtO2 at 15 min after injury (T15).
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NVX-108 increased PbtO2: peak 143% of T15 at 60 min after complete infusion.