Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats
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- 作者：Marie-Francoise Doursout ; Ph.D.a ; Marie-Francoise.Doursout@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author ; Yangyan Liang ; M.D.a ; Alamelu Sundaresan ; Ph.D.b ; Koji Wakame ; Ph.D.c ; Hajime Fujii ; Ph.D.c ; e ; Jun Takanari ; Ph.D.c ; e ; Sundar Devakottaia ; Anil Kulkarni ; Ph.D.d
- 关键词：AHCC ; Inflammation ; Hemodynamic ; Nitric oxide ; Gut ; Rats
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：280-286
- 全文大小：1392 K
文摘
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LPS-induced hypotension and sustained loss of blood flow into the splanchnic bed lead to gut mucosa atrophy
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The prebiotic, AHCC, is widely used in Chinese medicine for its anti-inflammatory and immuno-protective properties
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AHCC modulated LPS effects of blood pressure, inflammatory markers, lymphocyte infiltration and restored gut architecture
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AHCC is a novel therapeutic agent for treatment of hypotensive states commonly seen in acute inflammation patients.