- 作者：Stephan Bender ; Laura Melendez ; Johannes Schr?der ; Veit Roessner ; Franz Resch ; Matthias Weisbrod
- 关键词：Movement-related potentials ; Lateralization ; Schizophrenia ; Schizoaffective disorder ; Major depression
- 刊名：Clinical Neurophysiology
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：123
- 期：8
- 页码：1549-1560
- 全文大小：1659 K
Objective
To examine whether deficits in focal lateralized motor system activation would differentiate between subjects with schizophrenia/schizoaffective disorder and subjects with a major depressive episode. Reductions of Bereitschaftspotential amplitude have been described for both diagnostic groups.Methods
We analyzed multi-channel lateralized movement-related potentials (LMRP) during choice reaction movements in 16 schizophrenic/schizoaffective patients in partial remission with predominant negative symptoms, 18 patients with a non-psychotic major depression and two healthy control groups age-matched to the respective patient groups (20/23 subjects).
Results
A significant reduction of lateralized potentials over the (pre-)motor areas immediately preceding and around movement execution was found only in subjects with schizophrenia/schizoaffective disorder but not with a major depressive episode. Reduced LMRP amplitudes correlated with negative symptoms (SANS score). Other movement stages (preceding response-locked ¡®contingent negative variation¡¯ during response selection and post-movement evaluation during motor postimperative negative variation) were not affected in the same way.
Conclusions
Deficits in focal motor cortex activation during movement execution may reflect rather schizophrenia-specific deficits in fronto-striatal circuits. A general lack of drive and depressed mood did not alter the degree of lateralization of motor activation during movement execution.
Significance
Lateralization of movement-related potentials could differentiate psychotic from non-psychotic disorders on the group level.