Quality of Life and Functional Capacity in Patients With Atrial Fibrillation and Congestive Heart Failure

详细信息    查看全文

• 作者：Irina Suman-Horduna ; MD ; MSc^? ; Denis Roy ; MD^? ; Nancy Frasure-Smith ; PhD^? ; ^&dagger ; ; Mario Talajic ; MD^? ; Franç ; ois Lespé ; rance ; MD^&dagger ; ; Lucie Blondeau ; MSc^? ; Paul Dorian ; MD ; MSc^&Dagger ; ; Paul Khairy ; MD ; PhD^? ; ^{paul.khairy@umontreal.ca} ; AF-CHF Trial Investigators
• 关键词：atrial fibrillation ; functional capacity ; heart failure ; quality of life
• 刊名：Journal of the American College of Cardiology
• 出版年：2013
• 出版时间：29 January, 2013
• 年：2013
• 卷：61
• 期：4
• 页码：455-460
• 全文大小：219 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Objectives

This study sought to assess the impact of rhythm- versus rate-control treatment strategies and of underlying rhythm on quality of life and functional capacity in patients with atrial fibrillation (AF) and congestive heart failure (CHF).

Background

Although intention-to-treat and efficacy analyses have demonstrated similar cardiovascular outcomes in patients with AF and CHF randomized to rhythm or rate control, effects on quality of life remain to be determined.

Methods

The AF-CHF (Atrial Fibrillation and Congestive Heart Failure) trial randomized 1,376 patients to rhythm- or rate-control strategies. For this pre-specified substudy, Medical Outcomes Short Form-36 questionnaires were administered at baseline and 4 months. Six-min walk tests were conducted at baseline, 3 weeks, 4 months, and 1 year.

Results

Quality of life improved across all domains to a similar extent with rhythm and rate control. However, a higher proportion of time spent in sinus rhythm was associated with a modestly greater improvement in quality of life scores. Six-min walk distance (p = 0.2328) and New York Heart Association functional class (p = 0.1712) improved to a similar degree with rhythm and rate control. A higher proportion of time spent in sinus rhythm was associated with a greater improvement in New York Heart Association functional class (p < 0.0001) but not in 6-min walk distance (p = 0.1308).

Conclusions

Improvements in quality of life and functional capacity were similar in patients with AF and CHF randomized to rhythm- versus rate-control strategies. By contrast, sinus rhythm was associated with beneficial effects on New York Heart Association functional class and modest gains in quality of life. (Atrial Fibrillation and Congestive Heart Failure [AF-CHF]; )