Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17伪-ethinylestradiol
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- 作者：Lisa Baumanna ; b ; lisa.baumann@vetsuisse.unibe.ch" class="auth_mail ; Susanne Knö ; rrb ; susanne.knoerr@gmx.de" class="auth_mail ; Susanne Keiterb ; susanne.keiter@cos.uni-heidelberg.de" class="auth_mail ; Kristina Rehbergerb ; k.rehberger@stud.uni-heidelberg.de" class="auth_mail ; Sina Volzb ; s.volz@stud.uni-heidelberg.de" class="auth_mail ; Viktoria Schillerc ; schiller@molbiotech.rwth-aachen.de" class="auth_mail ; Martina Fenskec ; martina.fenske@ime.fraunhofer.de" class="auth_mail ; Henrik Holbechd ; hol@biology.sdu.dk" class="auth_mail ; Helmut Segnera ; helmut.segner@vetsuisse.unibe.ch" class="auth_mail ; Thomas Braunbeckb ; braunbeck@uni-hd.de" class="auth_mail
- 关键词：Vitellogenin ; Gonad histology ; Sexual differentiation ; Endocrine disruptor ; Aromatase ; Estrogen
- 刊名：Toxicology and Applied Pharmacology
- 出版年：1 August 2014
- 年：2014
- 卷：278
- 期：3
- 页码：230-237
- 全文大小：792 K
文摘
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Zebrafish were exposed to 17伪-ethinylestradiol during their sexual differentiation.
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Reversibility of effects was investigated after depuration of 40 days.
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Morphological and physiological parameters were compared.
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Zebrafish were able to recover at all different levels from mRNA to population.