The effectiveness and cost-effectiveness of intraoperative imaging in high-grade glioma resection; a comparative review of intraoperative ALA, fluorescein, ultrasound and MRI

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• 作者：M. Sam Eljamel ; ACG ; ABL ; MBBCh ; MD ; FRCSIr ; FRCEd ; IFRCS(SN) ; IFAANS ; ^{professor.ms.eljamel@gmail.com} (Prof.) ; Syed Osama Mahboob ; MBBS ; MRCS
• 关键词：ALA ; Cost-effectiveness ; FIGS ; Fluorescence ; Fluorescein ; Glioma ; Glioblastoma ; High-grade ; IoMRI ; IoUS ; Protoporphyrin IX ; Resection
• 刊名：Photodiagnosis and Photodynamic Therapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：Complete
• 页码：35-43
• 全文大小：1810 K
• 卷排序：16

文摘

ALA-FIGS in HGG has 82.6% sensitivity, 88.8% specificity, 97.4% PPV, 69.1% GTR and cost-effective cost/QALY. FLCN-FIGS in HGG has 86.6% sensitivity, 95.1% specificity, 84.4% GTR and cost-effective cost/QALY. IoUS in HGG has 95-88% sensitivity, 95-42% specificity, 98-62% PPV, 73.4% GTR and cost-effective cost/QALY. IoMRI in HGG has 55% sensitivity, 96% specificity, 70% GTR and cost-effective cost/QALY. There were no statistically significant differences between the different modalities in terms of GTR, sensitivity and specificity in HGG.