Early surgical occipitocervical stabilization for plasma cell neoplasms at the craniocervical junction: systematic review and proposal of a treatment algorithm

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• 作者：Sebastian A. Ahmadi ; MD ; ^{ahmadi@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author} ; Philipp J. Slotty ; MD ; Christopher Munoz-Bendix ; MD ; Hans-Jakob Steiger ; MD ; Jan Frederick Cornelius ; MD
• 关键词：Craniocervical junction ; Multiple myeloma ; Occipitocervical junction ; Plasmacytoma ; Spine ; Surgical treatment
• 刊名：The Spine Journal
• 出版年：2016
• 出版时间：1 January 2016
• 年：2016
• 卷：16
• 期：1
• 页码：91-104
• 全文大小：2504 K

文摘

Plasma cell neoplasms (PCNs) of the craniocervical junction (CCJ) are rare. Because of their destructive growth, PCNs may induce spinal instability and harbor the risk of sudden death. Therefore, PCNs at the CCJ require special consideration. Although the commonly used primary treatment of PCN is radiotherapy (RT), treatment guidelines are inexistent for CCJ occurrences.

Purpose

This study aimed to conduct a systematic review of the literature, evaluate the benefit of early and extended surgical treatment followed by RT, and outline a treatment algorithm based on the data gathered.

Study Design/Setting

Case series and systematic review of all reported cases in the English, Spanish and German medical literature were carried out.

Methods

Case series: retrospective clinical study, tertiary care center (2004–2014). Patients with a lesion of the CCJ (C0–C2) were identified. Clinical charts, imaging data, operative reports, and follow-up data were analyzed. Review: a systematic literature review was performed using PubMed. Further manuscripts were identified by the web search engine Google.

Results

Our series comprised four patients (one female, three males), mean age 58 years. There was one lesion of C1 and three of C2. Two patients with neck pain received vertebroplasty (C1 and C2, respectively) and RT as primary management. Both developed secondary instability of the CCJ after 12 and 5 months, respectively, and required occipitocervical stabilization (OCS). The other two patients underwent OCS and required no additional surgery and no signs of instability at follow-up. Forty-nine cases of OCS were published previously. Spinal stability was achieved significantly more frequently by OCS than by less invasive or medical interventional treatment options (p=.001; two-sided Fisher exact test).

Conclusions

Plasma cell neoplasms are highly radiosensitive. However, at the CCJ, a life-threatening instability may occur early and require surgical treatment. Based on personal experience, we favor OCS in this location. A systematic review of the literature supports this approach. We present a summary of our findings in a concise treatment algorithm for PCN of the CCJ.