Echocardiographic Estimation of Right Ventricular Stroke Work in Children with Pulmonary Arterial Hypertension: Comparison with Invasive Measurements

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• 作者：Michael V. Di Maria ; MD^a ; ^{michael.dimaria@childrenscolorado.org" class="auth_mail" title="E-mail the corresponding author} ; Dale A. Burkett ; MD^a ; Adel K. Younoszai ; MD^a ; Bruce F. Landeck II ; MD^a ; Luc Mertens ; MD^c ; D. Dunbar Ivy ; MD^a ; Mark K. Friedberg ; MD^c ; Kendall S. Hunter ; PhD^b
• 关键词：Pulmonary hypertension ; Right ventricular function ; Stroke work
• 刊名：Journal of the American Society of Echocardiography
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：28
• 期：11
• 页码：1350-1357
• 全文大小：1597 K

文摘

Right ventricular (RV) failure is a key determinant of mortality in children with pulmonary arterial hypertension (PAH). RV stroke work (RVSW) can be estimated as the product of RV systolic pressure and stroke volume. The authors have shown that RVSW predicts adverse outcomes in this population when derived from hemodynamic data; noninvasive assessment of RVSW may be advantageous but has not been assessed. There are few data validating noninvasive versus invasive measurements in children with PAH. The aim of this study was to compare echocardiographically derived RVSW with RVSW determined from hemodynamic data.

Methods

This was a retrospective study, including subjects with idiopathic PAH and minor or repaired congenital heart disease. Forty-nine subjects were included, in whom cardiac catheterization and echocardiography were performed within 1 month. Fourteen additional patients were included in a separate cohort, in whom catheterization and echocardiography were performed simultaneously. Catheterization-derived RVSW was calculated as RV systolic pressure × (cardiac output/heart rate). Echocardiographically derived RVSW was calculated as 4 × (peak tricuspid regurgitant jet velocity)² × (pulmonary valve area × velocity-time integral). Statistics included the intraclass correlation coefficient and Bland-Altman analysis.

Results

Echocardiographically derived RVSW was linearly correlated with invasively derived RVSW (r = 0.74, P < .0001, intraclass correlation coefficient = 0.76). Bland-Altman analysis showed adequate agreement. Echocardiographically derived RV work was related to indexed pulmonary vascular resistance (r = 0.43, P = .002), tricuspid annular plane systolic excursion (r = 0.41, P = .004), and RV wall thickness (r = 0.62, P < .0001).

Conclusions

The authors demonstrate that RV work, a potential novel index of RV function, can be estimated noninvasively and is related to pulmonary hemodynamics and other indices of RV performance.