Lack of effect of chronic ketamine administration on depression-like behavior and frontal cortex autophagy in female and male ICR mice
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- 作者：N.Z. Karaa ; b ; G. Agamb ; G.W. Andersonc ; N. Zitrona ; H. Einat ; Ph.D.a ; b ; c ; haimh@mta.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Animal model ; Affective disorders ; Glutamate ; Sex
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：576-580
- 全文大小：463 K
文摘
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Acute ketamine induces antidepressant-like behavior in female and male ICR mice.
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Chronic ketamine did not change depression-like behavior in female or male ICR mice.
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There were no behavioral differences between female and male ICR mice.
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Chronic ketamine did not induce changes in frontal cortex autophagy markers.