Morphometric analysis of gray matter integrity in individuals with early-treated phenylketonuria
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- 作者：Shawn E. Christa ; christse@missouri.edu" class="auth_mail" title="E-mail the corresponding author ; Mason H. Pricea ; Kimberly E. Bodnera ; Christopher Savillea ; Amanda J. Moffittb ; Dawn Peckc
- 关键词：PKU ; phenylketonuria ; PAH ; phenylalanine hydroxylase ; Phe ; phenylalanine ; LNAAs ; Large neutral amino acids ; ETPKU ; early-treated phenylketonuria ; GM ; gray matter ; MRI ; magnetic resonance imaging ; CBA ; cortex-based alignment ; FSIQ ; full scale intelligence quotient ; VBM ; voxel-based morphometry
- 刊名：Molecular Genetics and Metabolism
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：118
- 期：1
- 页码：3-8
- 全文大小：563 K
文摘
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Early-treated PKU associated with decreased parietal & occipital gray matter volume.
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No evidence of PKU-related differences in frontal or temporal gray matter volume.
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Tentative support for link between phe levels and effects on cortical gray matter.