Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

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• 作者：Hanaa H. Gaballah^a ; ^{hanaahibishy@hotmail.com} ; Rasha A. Gaber^a ; Darin A. Mohamed^b
• 关键词：Ehrlich tumor ; 5-FU ; Apigenin ; Autophay ; JNK activity ; Apoptosis
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：316
• 期：Complete
• 页码：27-35
• 全文大小：1692 K
• 卷排序：316

文摘

Apigenin potentiated 5-FU cytotoxicity in EAC solid tumor models in vivo. It acted via autophagy stimulation, downregulating MCL-1 and Ki-67 expression. It caused JNK activation and ROS accumulation; resulted in tumor growth inhibition. Apigenin can be used as a co-adjuvant agent in cancer therapy.