Blood levels of trace metals and amyotrophic lateral sclerosis
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- 作者：Tracy L. Petersa ; b ; John D. Bearda ; c ; David M. Umbachd ; Kelli Allene ; f ; Jean Kellerg ; Daniela Mariosab ; Dale P. Sandlera ; Silke Schmidth ; Fang Fangb ; Weimin Yeb ; Freya Kamela ; kamel@niehs.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIC ; Akaike information criterion ; ALS ; amyotrophic lateral sclerosis ; ALSFRS-R revised ; ALS functional rating scale ; CI ; confidence interval ; CSF ; cerebral spinal fluid ; Cu ; copper ; GENEVA ; Genes and Environmental Exposures in Veterans with ALS ; ICPMS ; inductively coupled plasma mass spectrometry ; Mn ; manganese ; MND ; motor neuron disease ; NHANES ; National Health and Nutrition Examination Survey ns not statistically significant ; OR ; odds ratio ; Pb ; lead ; RBCs ; red blood cells ; RR ; relative risk
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：119-126
- 全文大小：384 K
文摘
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We explored relationships of blood levels of trace metals to ALS risk.
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Lower selenium and zinc associated with greater ALS risk.
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Inverse associations with selenium and zinc stronger in those with worse function.
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Association of higher copper with greater ALS risk reduced by adjusting for lead.
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Relationships consistent with proposed ALS pathophysiological mechanisms.