Functional genetic polymorphisms in dopaminergic transporters: Association with ADHD traits in the Indian probands
详细信息 查看全文
- 关键词：ADHD ; Attention deficit hyperactivity disorder ; AD ; anxiety disorder ; CEPH ; population from Utah with ancestry from western and northern Europe ; CPRS-R ; Conners' Parent Rating Scale-revised ; DA ; dopamine ; DAT ; dopamine transporter ; DNA ; Deoxyribonucleic acid ; DSM-IV-TR ; Diagnostic and Statistical Manual of Mental Disorders-IV-text revised ; HCB ; Han Chinese from Beijing ; HHRR ; Haplotype based haplotype relative risk ; HWE ; Hardy-Weinberg equilibrium ; JPT ; Japanese from Tokyo ; Japan ; LD ; learning d
- 刊名：Meta Gene
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：11
- 期：Complete
- 页码：117-122
- 全文大小：467 K
- 卷排序：11
文摘
DAT and NET control motor activity, attention, mood swings, and stress induced anxiety, thus becoming targets for therapeutic intervention. Four functional variants in DAT and NET were analyzed for association with Attention-Deficit Hyperactivity Disorder associated traits in Family-based analysis exhibited statistically significant preferential transmission of gene variants. Association of gene variants with behavioral problems and co-morbid disorders were also observed. Data obtained for the first time evidenced association of DAT and NET gene variants with phenotypic traits and co-morbidity of Indian ADHD probands.