Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis

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• 作者：Anthony R. Rafferty^a ; ^b ; Colleen D'Arcy^c ; Leonie Cann^d ; Jan Pyman^c ; Peter Rogers^d ; Peter G. Davis^a ; ^b ; ^d ; Cameron Nowell^e ; David Burgner^a ; ^d ; ^e ; ^{david.burgner@mcri.edu.au}
• 关键词：Atherosclerosis ; Chorioamnionitis ; Funisitis ; Histopathology ; Intima-media thickness ; Umbilical artery
• 刊名：Placenta
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：40-43
• 全文大小：1373 K
• 卷排序：50

文摘

The fetal aorta or umbilical artery may show features of early atherosclerosis. We investigated whether chorioamnionitis with funisitis was pro-atherogenic. CD68 and CD45 positive cells significantly increased in the umbilical artery wall. SMA expression was down regulated in the umbilical artery wall. Chorioamnionitis with funisitis may promote atherogenic changes in fetal vasculature.