Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links
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- 作者：S.W. Hulberta ; Y.-H. Jianga ; b ; yong-hui.jiang@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASDs ; Autism spectrum disorders ; CNV ; copy number variant ; eIPSC ; evoked IPSC ; FMRP ; fragile X mental retardation protein ; FXS ; fragile X syndrome ; LOH ; loss of heterozygosity ; LTD ; long-term depression ; LTP ; long-term potentiation ; mEPSCs ; miniature excitatory postsynaptic currents ; mGluRs ; metabotropic glutamate receptors ; mIPSCs ; miniature inhibitory postsynaptic currents ; MSNs ; medium spiny neurons ; PHTS ; PTEN hamartoma tumor syndromes ; TSC ; tuberous sclerosis complex
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：321
- 期：Complete
- 页码：3-23
- 全文大小：826 K
文摘
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Disrupted synaptic function is common across mouse models of ASDs.
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The synapses affected and the magnitude and direction of effects are inconsistent.
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Overlapping molecular cascades include mGluR5, BDNF/TrkB, and mTOR signaling.
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The developmental origin and circuits underlying the disorders remain largely unknown.