No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover

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• 作者：J. John Mann ; Dianne Currier ; Lauren Murphy ; Yung-yu Huang ; Hanga Galfalvy ; David Brent ; Laurence Greenhill ; Maria Oquendo
• 关键词：TPH2 ; Single nucleotide polymorphism ; Bipolar disorder ; Major depressive disorder ; Suicide attempt
• 刊名：Journal of Affective Disorders
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：106
• 期：1-2
• 页码：117-121
• 全文大小：131 K

文摘

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. TPH2 is a recently discovered isoform that is expressed predominantly in serotonin neurons. Associations are reported of TPH2 polymorphisms with MDD, bipolar disorder and suicidal behavior. This study examines a single nucleotide polymorphism in the putative promoter region of the TPH2 gene.

Methods

One hundred nine bipolar, 324 major depressive disorder, and 130 healthy volunteers were genotyped for the rs4131347 (−C8347G) promoter SNP. Association was assessed with diagnosis, suicide attempt status, severity of psychopathology and cerebrospinal fluid monoamine metabolite levels of 5-HIAA, HVA, and MHPG. General linear models and logistic regression tested the effect of genotype childhood abuse interactions on psychopathology severity and suicide attempt.

Results

There was no association between genotype and either mood disorder, suicide attempt status, psychopathology severity or CSF monoamine metabolite levels.

Conclusions

No association was detected between the rs4131347 (−C8347G) SNP in the promoter region of the TPH2 gene and mood disorders, suicidal behavior or monoamine function.