Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task
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- 作者：Douglas C. Chang ; changdc@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Paolo Piaggi ; Joushua E. Burkholder ; Susanne B. Votruba ; Jonathan Krakoff ; Marci E. Gluck
- 关键词：Glucose ; Cognitive function ; Obesity ; Body composition ; Insulin ; Leptin
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：167
- 期：Complete
- 页码：392-398
- 全文大小：522 K
文摘
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Decision-making tested with the Iowa Gambling Task (IGT) after meal
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Measured body fat by DXA and insulin and leptin during oral glucose tolerance test
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Participants with lower insulin (30 min post-load) and body fat did better on IGT
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Lower leptin (30 min), rather than body fat, determined better IGT performance
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Leptin interacted with insulin and blunted effect of insulin at high leptin levels