Anticonvulsant medications attenuate amphetamine-induced deficits in behavioral inhibition but not decision making under risk on a rat gambling task
详细信息 查看全文
- 作者：Melanie Tremblay ; melanie.t@psych.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Catharine A. Winstanley ; cwinstanley@psych.ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：5CSRT ; 5 Choice Serial Reaction Time Task ; 5-HT ; 5-hydroxytryptamine ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; Amph ; amphetamine ; ANOVA ; analysis of variance ; BD ; bipolar disorder ; CBZ ; carbamazepine ; D ; dopamine receptor ; DA ; dopamine neurotransmitter ; DOI ; (+/&minus ; ) -1-(2 ; 5-dimethoxy-4-iodophenyl)-2-aminopropane ; g ; gram ; GABA ; gamma-aminobutyric acid ; HDAC ; histone deacetylase ; IGT ; Iowa Gambling Task ; IP ; intraperitoneal route ; ITI ; intertrial interval ; LMG ; lamotrigine
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：143-151
- 全文大小：1632 K
文摘
- •
Effect of valproate, lamotrigine and carbamazepine on a rat gambling task (rGT).
- •
Anticonvulsant drugs did not alter choice of various options on the rGT.
- •
Carbamazepine reduced motor impulsivity and increased choice latency on the rGT.
- •
Carbamazepine and valproate attenuated amphetamine-induced increase in impulsivity.
- •
Support for the use of carbamazepine and valproate in the control of impulsivity.