Involvement of aberrant calcium signalling in herpetic neuralgia
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- 作者：Rebekah A. Warwick ; rawarwick87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Menachem Hanani
- 关键词：ATP ; adenosine triphosphate ; GFAP ; glial fibrillary acidic protein ; HSV ; herpes simplex virus ; ICW ; intercellular calcium wave ; LY ; Lucifer yellow ; PRV ; pseudorabies virus ; SGC ; satellite glial cell ; TG ; trigeminal ganglia ; VZV ; varicella zoster virus
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：10-18
- 全文大小：1321 K
文摘
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We investigated how SGC-neuron communication is altered by HSV-1 infection.
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HSV-1 infection augmented intercellular calcium waves among sensory neurons and SGCs.
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HSV-1 infection induced cell fusion among sensory neurons and SGCs.
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HSV-1 infected neurons exhibited augmented influx of calcium upon depolarization.
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These changes are likely to be major contributing factors to herpetic neuralgia.