The effect of lead exposure on expression of SIRT1 in the rat hippocampus
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- 作者：Chang Fenga ; Junwang Gua ; Fankun Zhoua ; b ; 1 ; Jiaoyang Lia ; 1 ; Gaochun Zhuc ; 1 ; Linfu Guana ; Haizhen Liua ; Guihua Dua ; Jiangao Fengd ; Dong Liua ; Shuyun Zhanga ; Guangqin Fana ; b ; fanguangqin@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CREB ; cyclic AMP response element binding protein ; HLG ; high lead group ; LLG ; low lead group ; NMDAR ; N-methyl-d-aspartate receptor ; Pb ; lead ; PNW3 ; postnatal week 3 ; PNW52 ; postnatal week 52 ; SIR2 ; silent information regulator 2 ; SIRT1 ; silent information regulator 2 homolog 1
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：84-92
- 全文大小：1851 K
文摘
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SIRT1 has been reported to regulate CREB to maintain cognitive function.
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Effects of Pb on SIRT1 and CREB phosphorylation were detected in rat hippocampi.
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Pb exposure decreased SIRT1 and CREB phosphorylation.
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Resveratrol reversed Pb-induced decreases in SIRT1 and CREB phosphorylation.