Chronic benzodiazepine treatment decreases spine density in cortical pyramidal neurons
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- 作者：Yasmina Curtoa ; Clara Garcia-Mompoa ; Clara Bueno-Fernandeza ; Juan Nachera ; b ; c ; nacher@uv.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuronal structural plasticity ; Diazepam ; GABAA receptor agonist ; En passant boutons
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：613
- 期：Complete
- 页码：41-46
- 全文大小：1056 K
文摘
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Remodeling of excitatory neurons in parallel to change in GABAergic neurotransmission.
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Not known whether benzodiazepines modify structure of pyramidal neurons.
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Chronic treatment (21 days) with diazepam.
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Treated mice showed decrease in spine density in cingulate cortex pyramidal neurons