Ponciretin and poncirin inhibited IL-8 expression and NF-κB activation in ethanol- or LPS-stimulated KATO III cells Ponciretin and poncirin protected ethanol-induced gastric injury in mice Ponciretin and poncirin inhibited ethanol-induced secretion of CXCL-4 and IFN-γ in mice Ponciretin and poncirin inhibited ethanol-induced NF-κB activation in mice Anti-gastritis effect of ponciretin was greater than that of poncirin in vitro and in vivo.