Acromegaly and associated tumours: what should gastroenterologists know?

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• 作者：Marí ; a del Rosario Calder&oacute ; n^a ; ^{txaro@bizkaia.eu} ; Elvira Delgado^b ; Francisco Garcí ; a Campos^c
• 关键词：Acromegaly ; Neoplasms ; Growth hormone ; Colorectal adenoma ; Colorectal cancer
• 刊名：Gastroenterología y Hepatología (English Edition)
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：41-47
• 全文大小：564 K
• 卷排序：40

文摘

Acromegaly is a clinical syndrome caused by the excessive production of growth hormone. It is associated with high morbidity and significantly increased mortality, mainly due to cardiovascular and respiratory complications, and cancer. Mortality is reduced to that of the general population following successful treatment, in other words, when insulin-like growth factor (IGF-I) and growth hormone values return to normal levels. Not all tumours associated with this syndrome benefit from cost-effective early diagnosis programmes. An in-depth knowledge on the part of clinicians of the morbidity and mortality associated with acromegaly, allowing them in many cases to anticipate the expected clinical course of the disease, is the best therapeutic and follow-up strategy in these patients.