Programmable carbon nanotube membrane-based transdermal nicotine delivery with microdialysis validation assay

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• 作者：Gaurav Kumar Gulati ; PhD^a ; Tao Chen ; PhD ; MS^b ; Bruce Jackson Hinds ; PhD^a ; ^{bjhinds@uw.edu}
• 关键词：Microdialysis ; CNT membrane ; Nicotine ; Smoking cessation ; Remote counseling
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：1-9
• 全文大小：1122 K
• 卷排序：13

文摘

To evaluate the performance of switchable carbon nanotubes (CNT) membrane devices for transdermal nicotine delivery, we have developed an in-vitro microdialysis method that allow us to detect variable transdermal fluxes of nicotine through CNT devices and can be applied directly to in-vivo studies. Microdialysis membranes were placed beneath the porcine skin and its nicotine levels increased 6-8 times when the CNT membrane on skin was turned from OFF to ON state by application of bias. Fluxes in the ON state were approximately 3 times that of commercial nicotine patches and switching times were less than two hours, thus suggesting the improved therapeutic potential of our device. Blue tooth enabled CNT devices that can be programmed by smartphone and coupled with remote counseling application for enhanced smoking cessation treatments.