Surgical Implications of the Potential New Tubal Pathway for Ovarian Carcinogenesis

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• 作者：Gautier Chene ; MD^a ; ^{chenegautier@yahoo.fr} ; Kourosh Rahimi ; MD^b ; Ann-Marie Mes-Masson ; MD^a ; Diane Provencher ; MD^a
• 关键词：BRCA ; Laparoscopy ; Ovarian cancer ; Ovarian dysplasia ; Salpingectomy ; STIC
• 刊名：Journal of Minimally Invasive Gynecology
• 出版年：2013
• 出版时间：March-April, 2013
• 年：2013
• 卷：20
• 期：2
• 页码：153-159
• 全文大小：543 K

文摘

Since 2001, many studies by different investigators have demonstrated that the fallopian tube might be at the origin of most high-grade ovarian and peritoneal serous carcinomas. Simple changes in surgical practice (ie, prophylactic bilateral salpingectomy instead of salpingo-oophorectomy) could have significant implications for death from ovarian cancer and, on the other hand, for the morbidity caused by ovariectomy (surgical menopause). In this review, we describe the new tubal carcinogenic sequence, the advantages and disadvantages of exclusive use of salpingectomy in the general population, and in cases?of hereditary predisposition to ovarian cancer such as for carriers of BRCA mutation.