Neighbors' death is required for surviving human adenocarcinoma PC-9 cells in an early stage of gefitinib treatment
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- 作者：Masaki Takahashia ; b ; Masashi Fukuokaa ; Katsuji Yoshiokac ; Hirohiko Hohjoha ; hohjohh@ncnp.go.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：PC-9 cells ; Gefitinib ; Gefitinib resistance ; Epidermal growth factor receptor (EGFR) ; Fibroblast growth factor receptor (FGFR) ; FGF2
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：14 October 2016
- 年：2016
- 卷：479
- 期：2
- 页码：393-397
- 全文大小：437 K
文摘
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We focused on the survival of PC-9 cells exposed to gefitinib for the first time.
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We found extracellular FGF2 could confer survival to the cells exposed to gefitinib.
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FGF2 may be supplied from neighboring cells killed by gefitinib.
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Altruistic survival based on neighbors' death may occur in gefitinib-treated cells.