Effects of Sildenafil on Prognosis in Patients with Pulmonary Hypertension After Left-sided Valvular Surgery

详细信息    查看全文

• 作者：Gengxi Jiang ; MD ; Bailing Li ; MD ; Guanxin Zhang ; MD ; Enhong Xu ; MD ; Yang Liu ; MD ; Zhiyun Xu ; MD ; ^{smmxeh123@gmail.com" class="auth_mail}
• 关键词：Valvular heart disease ; Pulmonary artery hypertension ; Postoperative period ; Haemodynamic ; Sildenafil citrate
• 刊名：Heart, Lung and Circulation
• 出版年：July 2014
• 年：2014
• 卷：23
• 期：7
• 页码：680-685
• 全文大小：249 K

文摘

Sildenafil (Viagra, Pfizer) is being used to treat pulmonary hypertension (PH). However, there are limited data on the effects of sildenafil on patients with PH after left-sided valvular surgery. The purpose of this study was to determine the optimal dosage and the effects of sildenafil on prognosis of patients with PH after left-sided valvular surgery.

Methods

This randomised controlled trial, double-blind study enrolled patients with PH undergoing left-sided valvular surgery in our hospital from January to December, 2010. Ninety patients were enrolled. And 0.5 mg/kg sildenafil citrate or placebo was administered through nasogastric tubes, the haemodynamics changes in the 0.5/1/2/4 hours were assessed. The sildenafil citrate/placebo was continued to the discharges and the early prognoses of these patients were compared.

Results

Compared with placebo, a 0.5 mg/kg dose of sildenafil significantly reduced the time of mechanical ventilation, stay-in-ICU and hospitalisation duration.

Conclusions

Sildenafil might be beneficial to the early prognosis of patients with PH after left-sided valvular surgery.