New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors
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- 作者：Georges Moarbessa ; Jean-Franç ; ois Guichoub ; c ; Sté ; phanie Paniagua-Gayraudd ; Adrien Chouchoud ; Olivier Marcadetd ; Fiona Leroyd ; Ré ; mi Rué ; dasd ; Pierre Cuqd ; Carine Deleuze-Masqué ; fad ; carine.masquefa@umontpellier.fr" class="auth_mail" title="E-mail the corresponding author ; Pierre-Antoine Bonnetd
- 关键词：Imidazoquinoxalines ; IKK inhibitors ; NF-κB
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：115
- 期：Complete
- 页码：268-274
- 全文大小：830 K
文摘
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New Imidazoquinoxaline derivatives show potent and selective IKK2 inhibitory activity.
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Alkyl and aryl diversity is obtained in good yields under microwave assistance.
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Docking studies show specific hydrogen bonds interactions within the IKK2 binding site.