The kynurenine pathway and parasitic infections that affect CNS function

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• 作者：Nicholas H. Hunt ; ^{Nicholas.hunt@sydney.edu.au} ; Lay Khoon Too ; Loke Tim Khaw¹ ; Jintao Guo ; Leia Hee ; Andrew J. Mitchell² ; Georges E. Grau ; Helen J. Ball
• 关键词：Malaria ; Cerebral malaria ; Toxoplasma ; Kynurenine pathway ; Indoleamine 2 ; 3-dioxygenase ; Tryptophan ; Interferon-γ
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：part_PB
• 页码：389-398
• 全文大小：773 K
• 卷排序：112

文摘

The kynurenine pathway (KP) metabolises tryptophan to several biologically active compounds. Malaria and Toxoplasmosis are parasitic diseases that can affect CNS function. Infections with Plasmodium species or Toxoplasma gondii activate the KP. These KP disturbances may explain the impact of the two diseases on brain function. KP activation inhibits the growth of Toxoplasma but not Plasmodium.