Prevention and control of Hb Bart's Disease in Guangxi Zhuang Autonomous Region, China

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• 作者：Sheng He ; Qiang Zhang ; Dongming Li ; Shaoke Chen ; Yanqing Tang ; Qiuli Chen ; Chenguang Zheng ; ^{piger561220881@163.com" class="auth_mail}
• 关键词：Prevention and control ; Hb Bart's disease ; Prenatal diagnosis
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：July 2014
• 年：2014
• 卷：178
• 期：Complete
• 页码：138-141
• 全文大小：304 K

文摘

To demonstrate the performance of Hb Bart's Disease prevention in Guangxi Zhuang Autonomous Region, China.

Study design

A prenatal control program for Hb Bart's disease was conducted from January 2006 to December 2012. A total of 17,555 pregnant women were screened for 伪-thalassemia in our prenatal screening program. Pregnancy at-risk for Hb Bart's disease was offered the choice of direct invasive testing or the non-invasive approach with serial ultrasonography.

Results

A total of 1425 at-risk couples attended the prenatal diagnosis. Three hundred ninety couples were screened at our own hospital, and the remaining 1035 couples were referred from other hospitals. Two hundred and three pregnant women chose non-invasive approach, and 1122 chose invasive testing. A total of 365 fetuses were diagnosed with Hb Bart's disease. All cases were finally confirmed by fetal DNA analysis. Eighty-two cases (22.4%) were diagnosed by chorionic villous sampling and 194 (53.2%) by amniocentesis samples. The other 89 (24.4%) cases were performed by cordocentesis. All of the affected pregnancies were terminated.

Conclusion

Implementation of a prevention and control program accompanying with a referral system for prenatal diagnosis is technically feasible in Guangxi Zhuang Autonomous Region, China.