文摘
Neurovascular coupling was impaired in diabetic vs either non-diabetic (ND) or pancreatic islet transplanted-rats (TR). Pial arteriolar dilations to KCl and NS1619 were suppressed in diabetic rats, but not in ND or TR animals. These responses were completely restored by the acute application of a PKC inhibitor, GF109203X. Diabetes-associated chronic impairment of neurovascular coupling may be reversed by a PKC inhibitor. Diabetes-associated chronic impairment of neurovascular coupling may be prevented via pancreatic islet transplantation.