Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity
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- 作者：Angela Di Capuaa ; 1 ; Claudia Sticozzib ; Simone Brogia ; Margherita Brindisia ; Andrea Cappellia ; Lidia Sautebinc ; Antonietta Rossic ; Simona Pacec ; Carla Ghelardinid ; Lorenzo Di Cesare Mannellid ; Giuseppe Valacchib ; e ; Gianluca Giorgia ; Antonio Giordanif ; Giovanna Poceg ; Mariangela Biavag ; Maurizio Anzinia ; maurizio.anzini@unisi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX-2 inhibitors ; 1 ; 5-diarylpyrrole derivatives ; Anti-inflammatory agents ; Antinociceptive agents ; Antiproliferative activity ; Molecular modelling
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：99-106
- 全文大小：1148 K
文摘
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design, synthesis and biological evaluation of novel COX-2 selective inhibitors.
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COX-2 inhibitors are efficacious in the model of rat acute inflammatory pain.
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in vitro test demonstrated the potential antiproliferative activity on HaCaT cells.
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potential application of active compounds in the therapy of human skin disorders.