Characterization of DIP1, a novel nuclear protein in Drosophila melanogaster
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- 作者：De Felice ; Bruna ; Wilson ; Robert Roy ; Mondola ; Paolo ; Matrone ; Gianfranco ; Damiano ; Simona ; et. al.
- 关键词：Nuclear protein ; Drosophila ; Humans ; Nuclear periphery protein
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2003
- 出版时间：July 25, 2003
- 年：2003
- 卷：307
- 期：2
- 页码：224-228
- 全文大小：271 K
文摘
We have recently identified in Drosophila melanogaster a new gene encoding a nuclear protein, DIP1. Here we report the developmental expression and the finding that DIP1 subcellular localization is in the nucleus and at the nuclear periphery during interphase in embryos. Interestingly, in humans, DIP1 antibody identified signals in nuclei from cultured cells and reacted with a rough 30kDa protein in Western blotting experiments, demonstrating evolutionary conservation.