Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

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• 作者：Gilaad G. Kaplan¹ ; ² ; ^&lowast ; ; ^{ggkaplan@ucalgary.ca} ; Siew C. Ng³ ; ^&lowast ; ; ^{siewchienng@cuhk.edu.hk}
• 关键词：Crohn&rsquo ; s Disease ; Ulcerative Colitis ; Gene&ndash ; Environment Interaction ; Microbiota
• 刊名：Gastroenterology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：2
• 页码：313-321.e2
• 全文大小：1949 K
• 卷排序：152

文摘

The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized societies. The prevalence of IBD continues to increase steadily in Western countries, and newly industrialized countries have a rapidly increasing incidence. The global spread of IBD appears to associate with Westernization of diets and environments, which affects the intestinal microbiome and increases the risk of IBD in genetically susceptible individuals. It is important to increase our understanding of these events to slow progression of IBD. We present a long-term plan to develop interventions that slow or stop the global increase in the incidence of IBD.