Sauchinone from Saururus chinensis protects vascular inflammation by heme oxygenase-1 induction in human umbilical vein endothelial cells

详细信息    查看全文

• 作者：Bin Li ; Yun Jung Lee ; Youn Chul Kim ; Jung Joo Yoon ; So Min Lee ; Yong Pyo Lee ; Dae Gill Kang ; Ho Sub Lee
• 关键词：Sauchinone ; NF-魏B ; Heme oxygenase-1 ; HUVEC ; Atherosclerosis
• 刊名：Phytomedicine
• 出版年：15 January, 2014
• 年：2014
• 卷：21
• 期：2
• 页码：101-108
• 全文大小：2094 K

文摘

Sauchinone, a diastereomeric lignan isolated from the roots of Saururus chinensis (LOUR.) BAILL. (Saururaceae), is reported to exert a variety of biological activities such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cell adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) expression in high glucose stimulated human umbilical vein endothelial cells (HUVEC). Sauchinone inhibited the phosphorylation and degradation of I魏B-伪, as well as the nuclear translocation of nuclear factor kappa B (NF-魏B) p65 caused by the stimulation of high glucose. In addition, sauchinone induced heme oxygenase (HO)-1 expression through nuclear translocation of nuclear factor E2-related factor 2 in HUVEC. The effects of sauchinone on the high glucose-induced expression of VCAM-1 and ICAM-1 and nuclear translocation of NF-魏B p65 were partially reversed by transfection of the cells with HO-1 siRNA. These findings suggest that sauchinone-induced HO-1 expression plays a key role in the vascular protective effects of sauchinone in HUVEC.