Drug discovery targeting heme-based sensors and their coupled activities

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• 作者：Eduardo Henrique Silva Sousa^a ; ^{eduardohss@dqoi.ufc.br} ; Luiz Gonzaga de Franç ; a Lopes^a ; Gonzalo Gonzalez^b ; Marie-Alda Gilles-Gonzalez^b ; ^{marie-alda.gilles-gonzalez@utsouthwestern.edu}
• 关键词：Drug discovery ; Heme-based sensor ; Nucleotide cyclase ; Phosphodiesterase ; Histidine protein kinase ; Nuclear receptor
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：12-20
• 全文大小：1020 K
• 卷排序：167

文摘

Update on drug discovery to target medically relevant heme-based sensor proteins Strategies for targeting protein domains are discussed and their potential showed Regulators of soluble guanylate cyclase are described and their potential highlighted Perspectives on metabolic/mood disorder therapy using Rev-erb as a sensor target Molecules targeting c-di-GMP-related enzymes and histidine kinases as likely antibiotics