- 作者：Paolo Gisondi ; Giovanni Targher ; Anna Cagalli ; Giampiero Girolomoni
- 关键词：body mass index ; cardiovascular risk ; hyperuricemia ; psoriasis ; psoriatic arthritis ; uric acid
- 刊名：Journal of the American Academy of Dermatology
- 出版年：January, 2014
- 年：2014
- 卷：70
- 期：1
- 页码：127-130
- 全文大小：206 K
Background
Few studies have examined the association between elevated serum uric acid (SUA) levels and psoriasis, and their results have been inconclusive because most of these studies did not take into account the confounding effects of coexisting features of the metabolic syndrome.Objective
We compared the prevalence of hyperuricemia and SUA levels between psoriatic patients and control individuals.
Methods
Levels of SUA were measured in 119 consecutive psoriatic patients and 119 control individuals matched for age, sex, and body mass index.
Results
Compared with control subjects, psoriatic patients had higher SUA levels (5.61 卤 1.6 vs 4.87 卤 1.4 mg/dL; P < .001) and a remarkably greater prevalence of asymptomatic hyperuricemia (19% vs 7%; P < .001). Multivariate logistic regression analysis revealed that psoriasis was the strongest predictor of hyperuricemia (odds ratio 3.20; 95% confidence interval 1.32-7.58; P < .01) after adjusting for age, sex, and metabolic syndrome features.
Limitations
The cross-sectional design of this study does not allow us to draw any conclusion about a causal relation between psoriasis and hyperuricemia.
Conclusions
Hyperuricemia is a common finding in psoriatic patients. Its treatment might be clinically useful for the global treatment of patients.