Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

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• 作者：Joyce Zalotti Br ; t ; L铆via Teresa R. Silveira ; Tony Fern ; o Grassi ; Janete A. Anselmo-Franci ; Wagner Jos茅 F谩varo ; S茅rgio Luis Felisbino ; Luis Fern ; o Barbisan ; Wellerson Rodrigo Scarano
• 关键词：BPA ; bisphenol A ; GD ; gestational day ; I3C ; indole-3-carbinol ; PND ; postnatal day ; ED ; endocrine disrupter ; ER伪 ; estrogen receptor 伪 ; SD ; Sprague-Dawley ; DMSO ; dimethyl sulfoxide ; G1 ; control group (vehicle&#xA0 ; +&#xA0 ; basal chow) ; G2 ; BPA25-treated group (25&#xA0 ; 渭g/kg BPA) ; G3 ; BPA&#xA0 ; +&#xA0 ; I3C-treated group (25&#xA0 ; 渭g/kg BPA&#xA0 ; +&#xA0 ; basal chow containing I3C at 2&#xA0 ; g/kg) ; G4 ; BPA250-treated group (250&#xA0 ; 渭g/kg BPA) ; G5 ; BPA250&#xA0 ; +&#xA0 ; I3C-treated (250&#xA0 ; 渭g/kg BPA
• 刊名：Reproductive Toxicology
• 出版年：January, 2014
• 年：2014
• 卷：43
• 期：Complete
• 页码：56-66
• 全文大小：5003 K

文摘

Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 渭g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate.