Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): Evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation
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- 作者：Brittany M. Angle ; Rylee Phuong Do ; Davide Ponzi ; Richard W. Stahlhut ; Bertram E. Drury ; Susan C. Nagel ; Wade V. Welshons ; Cynthia L. Besch-Williford ; Paola Palanza ; Stefano Parmigiani ; Frederick S. vom Saal ; Julia A. Taylor
- 关键词：Metabolic syndrome ; Adipocytes ; Food intake ; Glucose tolerance ; Endocrine disruption
- 刊名：Reproductive Toxicology
- 出版年：December, 2013
- 年：2013
- 卷：42
- 期：Complete
- 页码：256-268
- 全文大小：1290 K
文摘
Exposure to bisphenol A (BPA) is implicated in many aspects of metabolic disease in humans and experimental animals. We fed pregnant CD-1 mice BPA at doses ranging from 5 to 50,000 渭g/kg/day, spanning 10-fold below the reference dose to 10-fold above the currently predicted no adverse effect level (NOAEL). At BPA doses below the NOAEL that resulted in average unconjugated BPA between 2 and 200 pg/ml in fetal serum (AUC0-24 h), we observed significant effects in adult male offspring: an age-related change in food intake, an increase in body weight and liver weight, abdominal adipocyte mass, number and volume, and in serum leptin and insulin, but a decrease in serum adiponectin and in glucose tolerance. For most of these outcomes non-monotonic dose-response relationships were observed; the highest BPA dose did not produce a significant effect for any outcome. A 0.1-渭g/kg/day dose of DES resulted in some but not all low-dose BPA outcomes.