Bisphenol A regulation of testicular endocrine function in male rats is affected by diet

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• 作者：Manjunatha K. Nanjappa^a ; Manuj Ahuja^b ; Muralikrishnan Dhanasekaran^b ; Elaine S. Coleman^a ; Tim D. Braden^a ; Frank F. Bartol^a ; R. Curtis Bird^c ; Desiree Wanders^a ; Robert L. Judd^a ; Benson T. Akingbemi^a ; ^{akingbt@auburn.edu" class="auth_mail}
• 关键词：Xenoestrogen ; Leydig cells ; Steroid hormones ; Adiponectin ; Oxidative stress
• 刊名：Toxicology Letters
• 出版年：21 March, 2014
• 年：2014
• 卷：225
• 期：3
• 页码：479-487
• 全文大小：2212 K

文摘

There is concern that early-life exposure to bisphenol A (BPA) may alter developmental programming and predispose individuals to obesity and reproductive anomalies. The present study was designed to determine if a high fat diet at sexual maturation moderates testicular toxicity occasioned by exposure to BPA during reproductive development. Therefore, male rats were exposed to BPA by maternal gavage (0, 2.5 or 25&#xA0;渭g/kg body weight/day) from gestational day 12 to postnatal day 21. At weaning, control and BPA-exposed animals were placed on a regular normal fat diet (NFD) until 70 days of age when they were continued on the NFD or were maintained on a high fat diet (HFD) until euthanasia at 98 days. Adult male rats maintained on HFD were generally heavier than NFD animals due to greater energy intake but energy intake per unit body weight gain was similar in all animals. However, perinatal exposure to BPA decreased (P < 0.05) serum adiponectin as well as adiponectin and AdipoR2 protein expression levels in Leydig cells. Importantly, the combination of BPA exposure and HFD consumption promoted lipid peroxidation evidenced by elevated serum thiobarbituric acid reactive substances and glutathione concentrations. These findings imply that interaction between BPA and HFD potentially causes testicular dysfunction to a greater degree than would be due to BPA exposure or HFD consumption. Given the relationship that exists between energy homeostasis and reproductive activity, additional studies are warranted to investigate the consequences of BPA-diet interactions on testicular function.